State Highway 1 (SH 1) is the main north south highway that runs along the Madison River, and serves the state's three largest cities: Charlotte, Madison, and Carsonville
Major intersections
| County
|
Location
|
Destination
|
| Carson
|
Carsonville
|
 - Preston Beach, Hatton
|
 - Orange, Cortland
|
 - Concord, Angroe
|
 - Concord, Easton City
|
| Renfro
|
 - Fairview
|
| Everett
|
 - Wellington
|
| Lawrence
|
Minersville
|
|
| - Woodway
|
 - Woodway, Redwood, West Monroe
|
| Gates
|
|
| Knight
|
Lyons
|
 - Anmark, Clay
|
| Ochoa
|
Wheaton
|
 - Huntington
|
| Smith
|
Grantsville
|
 - Smithville
|
| Jacksonville
|
South Park
|
 - Cambridge; Begin IR 5 Concurrency
|
| Osage
|
 - Hudson
|
| Commerce
|
 to   - Whitaker, Weston, Henderson
|
| South
|
Phelps
|
 - Newton, Henderson
|
| Starr
|
Ardmore
|
 - Seale, Kingston
|
| Madison River
|
| Chambers
|
Deweyville
|
|
| Deweyville
|
  - Tatum, East Madison
|
| Madison
|
Madison
|
- Downtown, Aneta
|
 - East Madison, Prestonburg
|
| - College Park, Eastpark
|
| Seale
|
West River Village
|
 - East River City
|
| Carter
|
Springdale
|
- Edgewood; Begin SH 35 Concurrency
|
| Cooke
|
Springhill
|
South - Edgewood; Begin I-75 Concurrency; End SH 35 Concurrency
|
| South Valley City
|
North - Charlotte; End I-75/IR-5 Concurrency
|
 - Parker
|
| Charlotte
|
Charlotte
|
 - Westridge, Trenton
|
 - South Charlotte, Parker
|
| - University Park
|
 to North  - South Charlotte, Longview, Houston, Petra
|
 - Madison, East Frankfort, Essex, Coronado, Ochoa
|
 - University Park, Damien
|
| - Highland Park, Parker
|
| Springwood
|
 - Elk Ridge
|
