Business IR 16 follows the original routing of the highway through downtown Jackson, Panamor. For most of its route, it is shares a roadway with Panamor State Route 215. The business route begins at an exit from Route 16 where it turns to bypass aroud the city, then runs south for a mile to join with SR 215. BUS 16 then follows SR 215 east through town to meet back up with mainline 16 at the exit for SR 215.